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Two simple and sensitive visible spectrophotometric methods have been developed for the estimation of Tolperisone in pure and pharmaceutical dosage forms. Method A is based on co-ordinate complex formation between the drug and cobalt thiocynate (630 nm) and method B is based on charge transfer complex formation between drug and 2,3 dichloro- 5-6-dicyano 1-4,benzoquinone (DDQ 430 nm) .The absorbance are measured against the corresponding reagent blanks. The methods have been statistically evaluated and found to be precise and accurate.
A simple and precise RPHPLC method was developed and validated for the determination of clopidogrel bisulphate in pharmaceutical dosage forms. Chromatography was carried out using Inertsil ODS-3 column with 250x4.6mm i.d, and having 5μ particle size was used. Acetonitrile:0.05%Formicacid (80:20) as the mobile phase at a flow rate 1.2 ml/min. The analyte was monitored using UV detector at 240 nm. The Retention time of the drug was 6.4min for clopidogrel bisulphate. The proposed method was found to have linearity in the concentration range of 7.5– 17.5 μg/ml. The developed method has been statistically validated and found simple and accurate in bulk and dosage forms.
